The Central Valley is Chile's largest wine region and includes several sub-regions, including Maipo and Cachapoal Valley. The climate in this region is Mediterranean, with hot and dry summers and mild winters. The Central Valley is also known for its fertile soils, which are ideal for grape growing.

Maipo Valley is located just south of Santiago, and its most famous wine is Cabernet Sauvignon. Maipo Cabernets are known for their ripe fruit flavors, bold tannins, and spicy notes. The region also produces some excellent Merlot and Carmenere wines, as well as some white wines like Chardonnay and Sauvignon Blanc.

Cachapoal Valley is further south of Maipo and is also known for its red wines. Cabernet Sauvignon is the most widely planted grape in this region, but Cachapoal Valley also produces excellent Carmenere and Syrah wines. The red wines from Cachapoal Valley are often characterized by their ripe fruit flavors, smooth tannins, and hints of spice.

Carignan is mainly grown in the Maule region of the Central Valley, where old-vine Carignan grapes are prized for their intense fruit flavors and rustic tannins. Some winemakers in Maule are focusing on producing high-quality, single-vineyard Carignan wines that showcase the grape's unique character.

Cabernet Franc is also grown in the Central Valley region, although it is typically used in blends rather than as a single varietal wine. Some winemakers in Chile are experimenting with Cabernet Franc, however, and are producing some excellent wines that showcase the grape's distinctive flavors of red fruit and green bell pepper.